PyBOP CAS 128625-52-5

PyBOP CAS 128625-52-5  Product Details

(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.

PyBOP CAS 128625-52-5 Product Picture

PyBOP CAS 128625-52-5 Application/Usage

Amides are ubiquitous in nature. Proteins are polymers (polyamides) whose units are linked by amide (peptide) bonds. Proteins perform countless functions in the body. Important synthetic polymers (technical products) such as nylon are also polyamides. Amides are therefore important elements in chemistry and biology, and therefore their synthesis has been a key area of research. Many methods are available for the synthesis of amides. Classic methods involve the preparation of amides from carboxylic acids and amines. The energetically unfavorable direct reaction between acids and amines is converted into a favorable pathway using coupling reagents.

Use coupling agents such as DCC and HOB. However, these reagents generate large amounts of waste. There are other selective methods, including Beckmann rearrangement, Schmidt reaction, Wigrod-Kindler reaction, Passerini reaction, etc. There has been a series of recent disclosures on alternative strategies for the synthesis of amides, with a focus on green or catalytic approaches. PyBOP has selective oxidation of alcohols and alkenes. It also had the potential to oxidize amines to amides, but it had not been studied earlier because green chemistry had not received much attention at the time. With the current focus on sustainability and green chemistry, scientists have begun using PyBOP to synthesize amides in a greener way. One way to obtain amides in a cleaner way is to oxidize amines to amides

PyBOP CAS 128625-52-5 Synonyms/tags/keywords

Amides，cas 128625-52-5,128625525，PyBOP ，C18H28F6N6OP2，PyBOP cas 128625-52-5，128625-52-5，PyBOP Novabiochem，Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate

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